In G6PD deficiency (XR), we have increased oxidative damage to RBCs, leading to intravascular hemolysis with decreased serum haptoglobin. We have decreased NADPH production, which means decreased conversion of oxidized ( S S ) glutathione Glucose 6 Phosphate Dehydrogenase Deficiency Hematology & Oncology UWorld Medical Library Glucose 6 phosphate dehydrogenase deficiency Knowledge @ AMBOSS File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons
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glutathione g6pd Glucose-6-Phosphate Dehydrogenase - an overview