Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Some alternatives to consider before jumping to Tylenol! I want to emphasize that I think the fear surrounding Tylenol can be a little unnecessary and intense. I do believe there are times Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect